within your playbook, all pending handlers will be executed.
You can then go on with you playbook
The doc also state that:
"Roles are described later on. It’s worthwhile to point out that handlers are automatically processed between ‘pre_tasks’, ‘roles’, ‘tasks’, and ‘post_tasks’ " http://docs.ansible.com/playbooks_intro.html#handlers-running-operations-on-change
So, if you need to run some tasks after you handlers have been fired, you can use a “post_tasks” section at the end of you playbook.